|
|
squalene <=> hop-22(29)-ene
|
5.4.99.17
squalene---hopene cyclase
|
–
|
MK
|
|
BRENDA:
BR40504;
BS380305
KEGG:
R07322
MetaCyc:
5.4.99.17-RXN
SABIO-RK:
6685
|
|
|
|
squalene + H2O <=> hopan-22-ol
|
4.2.1.129
squalene---hopanol cyclase
5.4.99.17
squalene---hopene cyclase
|
–
–
|
MK
|
|
BRENDA:
BR40505
KEGG:
R07323
MetaCyc:
RXN-4961
SABIO-RK:
6686
|
|
|
|
(2E,6E)-farnesyl_diphosphate + NADPH + H+ <=> squalene + diphosphate + NADP+
|
2.5.1.148
lycopaoctaene synthase
2.5.1.21
squalene synthase
|
–
–
|
K
|
|
BRENDA:
BR44279
KEGG:
R06223
MetaCyc:
RXN-13162
SABIO-RK:
5806
|
|
|
|
(2E,6E)-farnesyl_diphosphate + NADH + H+ <=> squalene + diphosphate + NAD+
|
2.5.1.21
squalene synthase
|
–
|
|
|
BRENDA:
BR44279-a
MetaCyc:
RXN-13162_WOP
|
|
|
|
squalene + diphosphate + NADP+ <=> presqualene_diphosphate + NADPH + H+
|
1.3.1.96
Botryococcus squalene synthase
1.3.1.97
botryococcene synthase
2.5.1.21
squalene synthase
|
–
–
–
|
BMK
|
|
BRENDA:
BR48481
KEGG:
R02872
MetaCyc:
RXN-13724;
RXN66-281
|
|
|
|
presqualene_diphosphate + NADH + H+ <=> squalene + NAD+ + diphosphate
|
2.5.1.21
squalene synthase
|
–
|
|
|
BRENDA:
BR48481-a
MetaCyc:
RXN66-281_WOP
|
|
|
|
tetrahymanol <=> squalene + H2O
|
4.2.1.123
tetrahymanol synthase
|
–
|
MK
|
|
BRENDA:
BR49622
KEGG:
R02875
MetaCyc:
RXN-12337
|
|
|
|
squalene <=> dammara-20,24-diene
|
5.4.99.37
dammaradiene synthase
|
–
|
MK
|
|
BRENDA:
BR49650
KEGG:
R09712
MetaCyc:
RXN-9895
|
|
|
|
S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + S-adenosyl-L-homocysteine + H+
|
2.1.1.262
squalene methyltransferase
|
–
|
|
|
BRENDA:
BR50273
KEGG:
R10169
MetaCyc:
RXN-13752
|
|
|
|
S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-homocysteine + H+
|
2.1.1.262
squalene methyltransferase
|
–
|
M
|
|
BRENDA:
BR50274
KEGG:
R10167
MetaCyc:
RXN-13284
|
|
|
|
squalene + FAD + H2O + H+ <=> hydroxysqualene + FADH2
|
1.17.8.1
hydroxysqualene dehydroxylase
|
–
|
M
|
|
BRENDA:
BR51747
KEGG:
R11401
MetaCyc:
RXN-17128
|
|
|
|
squalene + reduced_flavodoxin + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + flavin + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
K
|
|
BRENDA:
BR40381
KEGG:
R02874
|
|
|
|
squalene + NADPH + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS287895
SABIO-RK:
2736
|
|
|
|
squalene + reduced_acceptor + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + acceptor + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS375305;
BS394994
SABIO-RK:
2735
|
|
|
|
squalene <=> Hopanoid
|
not assigned
|
–
|
|
|
KEGG:
R02876
|
|
|
|
squalene <=> Hopane-29-acetate
|
not assigned
|
–
|
K
|
|
KEGG:
R08535
|
|
|
|
squalene + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + 2 ferricytochrome_b5 + H2O
|
1.14.19
|
–
|
K
|
|
KEGG:
R12355
|
|
|
|
squalene + O2 + reduced_[NADPH-hemoprotein_reductase] <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.17
squalene monooxygenase
|
–
|
M
|
|
MetaCyc:
SQUALENE-MONOOXYGENASE-RXN
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O <=> squalene + FADH2 + O2
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS451303
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene + 1-Carba-1-deazaFAD + H2O <=> squalene + 1-carba-1-deaza-FADH2 + O2
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS451305
|
|
|
|
squalene + reduced_cytochrome_P450 + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + cytochrome_P450 + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS394996
|
|
|
|
squalene + electron_donor + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + oxidized_electron_donor + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS370237
|
|
|
|
squalene + reduced_NADPH-cytochrome_P450_reductase + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + oxidized_NADPH-cytochrome_P450_reductase + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS451304
|
|
|
|
squalene <=> (+)-ambrein
|
4.2.1.B20
|
–
|
|
|
BRENDA:
BS445886
|
|
|
|
squalene + H2O <=> 8alpha-hydroxypolypoda-13,17,21-triene
|
4.2.1.B20
4.2.3.130
tetraprenyl-beta-curcumene synthase
|
–
–
|
|
|
BRENDA:
BS429400
|
|
|
|
squalene <=> (5E)-6,10-dimethyl-2-[(3R,3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldodecahydro-1H-cyclopenta[a]naphthalen-3-yl]undeca-5,9-dien-2-ol + H2O
|
4.2.1.B20
|
–
|
|
|
BRENDA:
BS445887
|
|
|
|
squalene + H2O <=> tetrahymanol + hopan-22-ol
|
4.2.1.123
tetrahymanol synthase
|
–
|
|
|
BRENDA:
BS417636
|
|
|
|
squalene <=> hop-22(29)-ene + hopan-22-ol
|
5.4.99.17
squalene---hopene cyclase
|
–
|
|
|
BRENDA:
BS427537
|
|
|
|
squalene + NADH + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP+ + H2O
|
1.14.14.17
squalene monooxygenase
|
–
|
|
|
BRENDA:
BS287895-a
|
|
|
|
(2E,6E)-farnesyl_diphosphate + phythyl_diphoshate + NADPH + H+ <=> squalene + (6E,10E,14E)-2,6,10,15,19,23,27-heptamethyloctacosa-2,6,10,14-tetraene + lycopadiene + NADP+
|
2.5.1.148
lycopaoctaene synthase
|
–
|
|
|
BRENDA:
BS440435
|
|